Journal of Indian Association of Pediatric Surgeons
Journal of Indian Association of Pediatric Surgeons
                                                   Official journal of the Indian Association of Pediatric Surgeons                           
Year : 2021  |  Volume : 26  |  Issue : 1  |  Page : 63--64

Multiple Cutaneous Malignancies in a Child with Xeroderma Pigmentosa


Padmapriya Balakrishnan1, Thirunavukkarasu Arun Babu2,  
1 Indira Gandhi Medical College and Research Institute, Puducherry, India
2 Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh, India

Correspondence Address:
Dr. Thirunavukkarasu Arun Babu
Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh
India




How to cite this article:
Balakrishnan P, Babu TA. Multiple Cutaneous Malignancies in a Child with Xeroderma Pigmentosa.J Indian Assoc Pediatr Surg 2021;26:63-64


How to cite this URL:
Balakrishnan P, Babu TA. Multiple Cutaneous Malignancies in a Child with Xeroderma Pigmentosa. J Indian Assoc Pediatr Surg [serial online] 2021 [cited 2021 Feb 28 ];26:63-64
Available from: https://www.jiaps.com/text.asp?2021/26/1/63/306710


Full Text



A 11-year-old boy with xeroderma pigmentosa (XP) presented with multiple ulcerated nodules in the right cheek, dorsum of the nose, forehead, right ear lobe and ulceroproliferative like growth over the left nasolabial fold [Figure 1]a and ulceroproliferative nodule over the right leg [Figure 1]b. Histopathology sections from skin lesions confirmed the simultaneous occurrence of three cutaneous malignancies, namely squamous cell carcinoma, basal cell carcinoma, and malignant melanoma [Figure 2]a,[Figure 2]b,[Figure 2]c.{Figure 1}{Figure 2}

XP is a rare genetically inherited disorder associated with oculocutaneous premalignant and malignant lesions and progressive neurodegeneration predominantly occurring during childhood and adolescence.[1] It is an autosomal recessive disorder caused by the impaired repair mechanism of ultraviolet-B rays-induced DNA damage to skin and eyes.[2] The main cutaneous clinical features include photosensitivity, pigmentary changes, premature skin aging, actinic keratosis, and development of multiple cutaneous malignancies, more commonly basal cell carcinoma, squamous cell carcinoma, malignant melanoma, and fibrosarcoma.[1],[2]

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

1Shankar R, Qureshi SS, Sugoor P, Kembhavi S, Yadav PS, Mukta R. Colossal squamous cell carcinoma of the face in a child with xeroderma pigmentosum. J Indian Assoc Pediatr Surg 2014;19:185-6.
2Singh AP, Ansari M, Shukla AK. Basal cell carcinoma with xeroderma pigmentosum in an 8-year-old girl. J Indian Assoc Pediatr Surg 2019;24:314-6.