Journal of Indian Association of Pediatric Surgeons
Journal of Indian Association of Pediatric Surgeons
                                                   Official journal of the Indian Association of Pediatric Surgeons                           
Year : 2019  |  Volume : 24  |  Issue : 1  |  Page : 68--71

Hepatoblastoma with precocious puberty


Enono Yhoshu, Yasir A Lone, Jai K Mahajan, Umesh Bahadur Singh 
 Department of Pediatric Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Dr. Jai K Mahajan
Department of Pediatric Surgery, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012
India

Hepatoblastoma (HB), a primary liver tumor of childhood, is often accompanied by raised levels of alpha-fetoprotein (α-FP). Rarely, the beta-human chorionic gonadotropin (β-hCG) levels may also be elevated, which can cause peripheral precocious puberty (PPP). We report a case of HB with precocious puberty wherein hormonal assays showed an increase in α-FP, β-hCG, and testosterone levels, and suppression of follicle-stimulating and luteinizing hormone levels. After chemotherapy and surgery, α-FP, β-hCG, and testosterone levels normalized, and the signs of virilization did not progress further. New therapeutic approaches have made a previously reported grim prognosis of virilizing HB, more favorable now. In the assessment of PPP, the possibility of a tumoral source for the hormones should also be considered.


How to cite this article:
Yhoshu E, Lone YA, Mahajan JK, Singh UB. Hepatoblastoma with precocious puberty.J Indian Assoc Pediatr Surg 2019;24:68-71


How to cite this URL:
Yhoshu E, Lone YA, Mahajan JK, Singh UB. Hepatoblastoma with precocious puberty. J Indian Assoc Pediatr Surg [serial online] 2019 [cited 2020 Nov 27 ];24:68-71
Available from: https://www.jiaps.com/article.asp?issn=0971-9261;year=2019;volume=24;issue=1;spage=68;epage=71;aulast=Yhoshu;type=0