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Journal of Indian Association of Pediatric Surgeons
     Journal of Indian Association of Pediatric Surgeons
Official journal of the Indian Association of Pediatric Surgeons         
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LETTERS TO THE EDITOR
Year : 2020  |  Volume : 25  |  Issue : 6  |  Page : 417-418
 

A novel method to predict early neurologic recovery after pediatric spine surgery


Department of Anaesthesiology, Government Medical College, Thiruvananthapuram, Kerala, India

Date of Submission01-Mar-2020
Date of Decision07-Mar-2020
Date of Acceptance27-Mar-2020
Date of Web Publication27-Oct-2020

Correspondence Address:
Dr. Varun Suresh
Department of Anaesthesiology, Government Medical College, Thiruvananthapuram, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jiaps.JIAPS_54_20

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How to cite this article:
Suresh V. A novel method to predict early neurologic recovery after pediatric spine surgery. J Indian Assoc Pediatr Surg 2020;25:417-8

How to cite this URL:
Suresh V. A novel method to predict early neurologic recovery after pediatric spine surgery. J Indian Assoc Pediatr Surg [serial online] 2020 [cited 2020 Nov 28];25:417-8. Available from: https://www.jiaps.com/text.asp?2020/25/6/417/299206




Sir,

Pediatric spinal extradural hemorrhage (EDH), though rare, can result in serious complications if diagnosis and treatment are delayed.[1] Spontaneous bleeds, traumatic, bleed after lumbar puncture, spinal cord arteriovenous malformations or tumors, and anticoagulant therapy are etiopathogenic to the onset of spinal EDH.[2] Children with spinal EDH require emergency surgery. Intraoperative neuromonitoring (IONM) assists in the early detection of periprocedural spinal cord injury.[3],[4]

A 10-year-old previously healthy child weighing 29 kg presented to us with sudden-onset weakness of the bilateral lower limbs progressing over 72 h. There was no significant past/family history or history of trauma. Clinical examination revealed spastic paraparesis and exaggerated deep tendon reflexes with 4/5 power of both lower limbs. Magnetic resonance imaging of the spine revealed a C6–D3 vertebral level posterior and left posterolateral epidural hemorrhage with spinal cord compression and spinal cord edema [Figure 1]. A clinical diagnosis of spontaneous spinal epidural hemorrhage (SSEH) was made, and the case was scheduled for emergency decompression of spinal hematoma under general anesthesia (GA). IONM, though a standard of care in our hospital, could not be mobilized due to exigency of time considering the emergency nature of the surgery.
Figure 1: Magnetic resonance image of the spine showing T2 hypo–isointense lesion from C5–D3 vertebral level with spinal cord compression and edema suggestive of extradural hemorrhage

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In the operating room, GA was induced with intravenous (IV) fentanyl 3 mcg/kg and propofol 2 mg/kg. We obtained a baseline train-of-four (TOF) stimulation ratio before administering skeletal muscle relaxant. Baseline TOF ratio recorded was 50%. Subsequently, endotracheal intubation was facilitated with IV succinylcholine 2 mg/kg. Total IV anesthesia was used for GA maintenance with IV continuous infusions of fentanyl and propofol targeted to a bispectral index of 40–60. No further skeletal muscle relaxants were used during the maintenance of GA. The patient underwent decompressive spinal laminectomy and evacuation of hematoma from C6 to D3 level in the prone operative position under GA. TOF ratios were continuously recorded throughout the duration of surgical procedure at an interval of 10 min. TOF ratios increased intraoperatively to 90% on complete evacuation of hematoma. The surgical procedure was otherwise uneventful. The child had minimal spasticity of both lower limbs and could be ambulated by the 2nd postoperative day.

TOF ratio is classically used intraoperatively to monitor response and recovery to skeletal muscle relaxants.[5] A “fade” is characteristic of nondepolarizing skeletal muscle relaxant whereas TOF ratio is maintained, but the amplitude of response reduced, with the use of succinylcholine. The reduced baseline TOF and recovery in TOF ratio toward the completion of procedure in our case can, respectively, be attributed to symptomatic compressive myelopathy due to acute-onset SSEH and recovery in neurologic function after decompression of SSEH. Transcranial motor evoked potentials induced compound muscle action potentials can better predict such neuronal recovery,[4] however; this could not be used in our case considering the emergent requirement of surgery. It might be too premature to reach a conclusion that the increment in TOF ratios can predict neurologic recovery, though our case presents a simple yet novel such application of intraoperative TOF in acute spinal cord compressive myelopathy. Case series of TOF recovery in a larger number of patients with symptomatic myelopathy undergoing spinal decompression/instrumentation can consolidate our findings.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Patel H, Boaz JC, Phillips JP, Garg BP. Spontaneous spinal epidural hematoma in children. Pediatr Neurol 1998;19:302-7.  Back to cited text no. 1
    
2.
Poonai N, Rieder MJ, Ranger A. Spontaneous spinal epidural hematoma in an 11-month-old girl. Pediatr Neurosurg 2007;43:121-4.  Back to cited text no. 2
    
3.
Kim SM, Kim SH, Seo DW, Lee KW. Intraoperative neurophysiologic monitoring: Basic principles and recent update. J Korean Med Sci 2013;28:1261-9.  Back to cited text no. 3
    
4.
Calancie B, Harris W, Broton JG, Alexeeva N, Green BA. “Threshold-level” multipulse transcranial electrical stimulation of motor cortex for intraoperative monitoring of spinal motor tracts: Description of method and comparison to somatosensory evoked potential monitoring. J Neurosurg 1998;88:457-70.  Back to cited text no. 4
    
5.
Duţu M, Ivaşcu R, Tudorache O, Morlova D, Stanca A, Negoiţă S, et al. Neuromuscular monitoring: An update. Rom J Anaesth Intensive Care 2018;25:55-60.  Back to cited text no. 5
    


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