| CASE REPORT |
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| Year : 2019 | Volume
: 24
| Issue : 1 | Page : 68-71 |
Hepatoblastoma with precocious puberty
Enono Yhoshu, Yasir A Lone, Jai K Mahajan, Umesh Bahadur Singh
Department of Pediatric Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Correspondence Address:
Dr. Jai K Mahajan
Department of Pediatric Surgery, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jiaps.JIAPS_102_18
Hepatoblastoma (HB), a primary liver tumor of childhood, is often accompanied by raised levels of alpha-fetoprotein (α-FP). Rarely, the beta-human chorionic gonadotropin (β-hCG) levels may also be elevated, which can cause peripheral precocious puberty (PPP). We report a case of HB with precocious puberty wherein hormonal assays showed an increase in α-FP, β-hCG, and testosterone levels, and suppression of follicle-stimulating and luteinizing hormone levels. After chemotherapy and surgery, α-FP, β-hCG, and testosterone levels normalized, and the signs of virilization did not progress further. New therapeutic approaches have made a previously reported grim prognosis of virilizing HB, more favorable now. In the assessment of PPP, the possibility of a tumoral source for the hormones should also be considered.
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