| ORIGINAL ARTICLE
|Year : 2018 | Volume
| Issue : 2 | Page : 81-86
Ratio of preoperative and postoperative serum bilirubin levels predicts early outcome following biliary atresia surgery
Kashish Khanna1, Veereshwar Bhatnagar1, Sandeep Agarwala1, Maddur Srinivas1, Siddhartha Datta Gupta2
1 Department of Pediatric Surgery, All Institute of Medical Sciences, New Delhi, India
2 Department of Pathology, All Institute of Medical Sciences, New Delhi, India
Aim: This study investigates the fall in total serum bilirubin levels within 1 week after surgery, as a marker to predict early outcome in biliary atresia (BA) patients post-Kasai portoenterostomy (KP).
Methods: The ratio of total serum bilirubin levels at the 7th postoperative day to the preoperative level (TB7/TB0) in patients undergoing KP was calculated (January 2011–July 2015). Patients were stratified after 3-months follow-up into outcome groups depending on the clinical clearance of jaundice and TB7/TB0 ratio was correlated to outcome and liver histopathological changes in these groups.
Results: Sixty-one patients (M:F = 44:17), median age 75 days were included. At the end of 3 months, 27 (44.39%) were anicteric while 26 (42.6%) were still clinically jaundiced. Patients with a higher median value of TB7/TB0, that is, 0.856 were more likely to have jaundice at the end of 3 months as compared to patients with a lower median value of 0.615 (P < 0.0001). A cutoff TB7/TB0 ratio >0.723 predicted the KP outcome with 84.6% sensitivity and 81.5% specificity. The difference in TB7/TB0 ratio between patients with varying severity of liver histopathological changes was also significant, namely, cholestasis (P = 0.01), hepatocellular damage (P = 0.03), portal inflammation (P = 0.04), and portal fibrosis (P = 0.02).
Conclusions: The rapidity of fall in the total serum bilirubin levels within 1 week post-KP was able to predict the likely outcome in BA patients.
Department of Pediatric Surgery, All India Institute of Medical Sciences, Room No. 4002, 4th Floor, New Delhi - 110 029
Source of Support: None, Conflict of Interest: None
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