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LETTER TO THE EDITOR |
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| Year : 2015 | Volume
: 20
| Issue : 1 | Page : 52 |
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Bile in various hepatobiliary disease states
Sim Sai Tin1, Viroj Wiwanitkit2
1 Medical Science Unit, Hainan Medical University, China
2 Visiting Professor in Tropical Medicine Unit, Hainan Medical University, China
| Date of Web Publication | 27-Nov-2014 |
Correspondence Address:
Sim Sai Tin
Medical Center, Shantou
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0971-9261.145562
How to cite this article:
Tin SS, Wiwanitkit V. Bile in various hepatobiliary disease states
. J Indian Assoc Pediatr Surg 2015;20:52 |
Sir,
We would like to discuss the report on "bile in various hepatobiliary disease states." [1] Verma et al. concluded that the components of bile show a close correlation with various clinical and prognostic markers. There is a very close correlation between these parameters and the clinical severity, disease progression and final outcome. [1] In fact, bile analysis is an old laboratory test in body fluid examination. Based on the report by Verma et al., the analysis might seem useful in clinical diagnosis. However, there are some concerns to be addressed. First, the bile component can be affected by several physiological and pathological conditions. For example, dehydration in children might concentrate the bile. [2] In addition, some underlying genetic diseases such as hemoglobinopathies might alter the component of the bile. [3] These factors have to be considered in bile analysis; however, it is not well assessed and mentioned in the report by Verma et al. [1]
 References | |  |
| 1. | Verma A, Bhatnagar V, Prakash S, Srivastava AK. Analysis of bile in various hepatobiliary disease states: A pilot study. J Indian Assoc Pediatr Surg 2014;19:151-5.  [ PUBMED]  |
| 2. | Devor AW, Marlow HW. Dehydration of cholic acid. J Am Chem Soc 1946;68:2101. [ PUBMED] |
| 3. | Barbi G, Annoni G. Thalassemia trait and the lithogenicity of bile. Minerva Med 1977;68:2997-3000. [ PUBMED] |
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