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Journal of Indian Association of Pediatric Surgeons
     Journal of Indian Association of Pediatric Surgeons
Official journal of the Indian Association of Pediatric Surgeons         
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Year : 2005  |  Volume : 10  |  Issue : 4  |  Page : 237-243

Liver tryptase-positive mast cells and fibrosis in children with hepatic echinococcosis

1 Department of General and Clinical Pathology, Trakia University, Stara Zagora, Bulgaria
2 Department of Chemistry and Biochemistry, Trakia University, Stara Zagora, Bulgaria
3 Department of Surgery, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
4 Department of Anatomy, Trakia University, Stara Zagora, Bulgaria

Correspondence Address:
Maya Gulubova
Trakia University, Medical Faculty, Department of General and Clinical Pathology, 11 Armeiska Str., Stara Zagora, 6000
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-9261.19273

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The hepatic echinococcosis in children is a serious surgical problem. The aim of this study is to investigate the participation of mast cells in liver inflammatory reactions triggered by echinococcal cysts. Liver biopsy samples were collected from the tissue surrounding the cysts from 16 sick children (11 boys and 5 girls) in the course of abdominal surgery and from 5 controls. Light and ultrastructural immunocytochemistry was performed using monoclonal antibody against tryptase. Light microscopical immunocytochemistry revealed abundance of tryptase-positive (MCT) mast cells in the capsules of the cysts (43.58 cells/mm2). There were also observed greatly increased numbers of mast cells in portal tracts surrounding the cyst, compared to those of control biopsies (26.49 vs. 1.78 cells/mm2, p=0.0009, Mann-Whitney U test). Based on the ultrastructural appearance of tryptase-positive mast cell granules, morphological sings of activation of most of the mast cells were distinguished. In conclusion, we suggest that the accumulated and activated tryptase-positive mast cells in liver tissues surrounding the echinococcal cysts play a crucial role in modulation of the inflammatory liver response and could induce chronic inflammation and fibrogenesis, resulting in serious liver injury such as nonspecific reactive hepatitis.


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  2005 - Journal of Indian Association of Pediatric Surgeons | Published by Wolters Kluwer - Medknow 

Online since 1st May '05