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Journal of Indian Association of Pediatric Surgeons
     Journal of Indian Association of Pediatric Surgeons
Official journal of the Indian Association of Pediatric Surgeons         
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Year : 1996  |  Volume : 1  |  Issue : 1  |  Page : 13-16

Relationship between threatened abortion and congenital malformations

Department of Paediatric Surgery, Institute of Maternal and Child Health, Calicut, Kerala

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PY Henry
Department of Paediatric Surgery, Institute of Maternal and Child Health, Calicut, Kerala

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Source of Support: None, Conflict of Interest: None

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ABSTRACT: It is established that the incidence of major congenital malformations among the preterm infants was higher-almost 1 in 12 preterm in fants. This study is aimed to find out whether congenitally malformed foetuses are naturally aborted and conversely whether spontaneous abortions are atleast in some cases due to foetal anomaly. A three fold targetting was envisaged to study this relationship between spontaneous abortion and congenital malformations. 1) A retrospective study of woman who had threatened abortion, during the year 1984, 1985 and 1986. 2) A prospective study of women who were admitted with threatened abortion during the year 1988-89. 3) All infants and children who had multiple congenital anomalies were included in this group. A thorough antenatal history of their mothers were taken for the presence of uterine bleeding indicating abortion. In this retrospective study of women, who had threatened abortion, but did not complete the process of abortion, incidence of major life threatening congenital malformations come to 1 in 12.8. Prospective study of women yield an incidence of major congenital anomalies of 1 in 8.6. In children with major congenital malformations observed during the period, the abortion related risk factors were present in 1/3rd. Overall incidence of major congenital anomalies was 1:400 deliveries. Thus a high positive relationship between threatened abortion and major life threatening congenital malformation is proved in this study. It is therefore concluded that interfering with the process of abortion with drugs is not to be recommended except in extraordinary circumstances

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  2005 - Journal of Indian Association of Pediatric Surgeons | Published by Wolters Kluwer - Medknow 

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