Journal of Indian Association of Pediatric Surgeons
Journal of Indian Association of Pediatric Surgeons
                                                   Official journal of the Indian Association of Pediatric Surgeons                           
Year : 2019  |  Volume : 24  |  Issue : 1  |  Page : 52--60

Synchronous bilateral wilms tumor: Five-year single-center experience with assessment of quality of life


Hinglaj Saha1, Dipak Ghosh1, Somak Kumar Biswas1, Prafulla Kumar Mishra1, Kaushik Saha1, Uttara Chatterjee2 
1 Department of Paediatric Surgery, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India
2 Department of Pathology, SSKM and IPGMER Medical College and Hospital, Kolkata, West Bengal, India

Correspondence Address:
Dr. Dipak Ghosh
Orbit Sky View, 1/1A, Umakanta Sen Lane, Block 4, Flat-4B, Kolkata - 700 030, West Bengal
India

Context: Synchronous Bilateral Wilms tumor (sBWT). Aims: This study aimed to assess the outcome of patients with sBWT treated on SIOP protocol. Settings and Design: Retrospective and prospective randomized study. Subjects and Methods: SIOP 93-01 protocol was used to study nine patients of sBWT in a single center and followed up over a period from 2 to 5 years. Statistical Analysis Used: Unpaired t-test and Mann–Whitney U-test were used for analysis. Results: Of nine patients, six were included in the study as three patients lost to follow-up. Among the six patients, there were four girls and two boys with a median age of 2 years. Mean regression in the size of tumor was 87% in four out of six patients. Tumor with unfavorable histology showed 32% response (ratio of favorable: unfavorable histology 2:1). Event-free survival rate was 81.3% and overall survival was 90% over 2–5 years. Recurrence was seen in two patients of whom one had Denys–Drash syndrome. Mean DTPA glomerular filtration rate was 91.4/ml/min/1.73 m2 preoperatively and that of 3 months after completion of treatment was 84/ml/min/1.73 m2. Health-related quality of life (HRQOL) using Pediatric Quality of Life Inventory and Lansky Play Performance Scale revealed significant improvement results of all functioning domains such as physical, social, emotional, and school subscales with P < 0.05 and performance scale (P < 0.04). Conclusions: We suggest SIOP protocol for sBWT and bilateral nephron-sparing surgery in two stages. However, long-term follow-up is required to assess the ultimate renal function outcome. HRQOL is an essential guide in improving the conditions of pediatric cancer survivors.


How to cite this article:
Saha H, Ghosh D, Biswas SK, Mishra PK, Saha K, Chatterjee U. Synchronous bilateral wilms tumor: Five-year single-center experience with assessment of quality of life.J Indian Assoc Pediatr Surg 2019;24:52-60


How to cite this URL:
Saha H, Ghosh D, Biswas SK, Mishra PK, Saha K, Chatterjee U. Synchronous bilateral wilms tumor: Five-year single-center experience with assessment of quality of life. J Indian Assoc Pediatr Surg [serial online] 2019 [cited 2020 Sep 21 ];24:52-60
Available from: http://www.jiaps.com/article.asp?issn=0971-9261;year=2019;volume=24;issue=1;spage=52;epage=60;aulast=Saha;type=0