Journal of Indian Association of Pediatric Surgeons
Journal of Indian Association of Pediatric Surgeons
                                                   Official journal of the Indian Association of Pediatric Surgeons                           
Year : 2013  |  Volume : 18  |  Issue : 2  |  Page : 53--57

Nephrectomy in children: Comparison of stress response to laparoscopic and open methods


Virender Sekhon1, Prema Menon1, Sunil Arora2, K. L. N. Rao1 
1 Department of Pediatric Surgery, Advanced Pediatric Center, Chandigarh, India
2 Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Prema Menon
Department of Pediatric Surgery, Advanced Pediatric Center, Post Graduate Institute of Medical Education and Research, Chandigarh
India

Aim: To evaluate and compare the extent of surgical stress following laparoscopic nephrectomy (LN) and open nephrectomy (ON) in children. Materials and Methods: Twenty consecutive children undergoing nephrectomy were randomized to LN or ON groups. Acid-base balance, blood glucose, acute phase proteins (C-reactive protein [CRP]) and inflammatory markers (interleukin-6 [IL-6]) were measured pre-operatively, as well as 4 and 24 h after surgery. The differences between the two groups were analyzed statistically (significance value for P < 0.05). Results: The overall acid base status was more stable in LN. The fall in pH 4 h after surgery was more in ON (P = 0.440) and the difference in pH in ON 4 h and 24 h post-operatively was statistically significant (P = 0.002). In LN, significant difference was found in the base excess mean pre-surgery (mean -3.280 mEq/L) and 4 h post-surgery (mean -7.480 mEq/L) (P = <0.05), as well as between 4 h and 24 h after surgery (mean -2.660 mEq/L) (P = 0.011).The acute rise in CRP 24 h post-operatively in the ON (88.972 mg/L) was significantly higher when compared to both the pre-operative and 4 h post-operative values (P < 0.05). This rise was however, not statistically significant when compared to the 24 h post-operative value in LN (46.399 mg/L) (P = 0.062). The rise in IL-6, 24 h post-procedure in LN (mean 44.444 pg/ml) was statistically lower than that in the open group (mean 343.333 pg/ml) (P = 0.041). Conclusions: The stable acid-base status and lesser rise of CRP and IL-6 in LN lead to the conclusion that surgical stress caused by LN is less than ON.


How to cite this article:
Sekhon V, Menon P, Arora S, Rao K. Nephrectomy in children: Comparison of stress response to laparoscopic and open methods.J Indian Assoc Pediatr Surg 2013;18:53-57


How to cite this URL:
Sekhon V, Menon P, Arora S, Rao K. Nephrectomy in children: Comparison of stress response to laparoscopic and open methods. J Indian Assoc Pediatr Surg [serial online] 2013 [cited 2020 Jan 21 ];18:53-57
Available from: http://www.jiaps.com/article.asp?issn=0971-9261;year=2013;volume=18;issue=2;spage=53;epage=57;aulast=Sekhon;type=0