Journal of Indian Association of Pediatric Surgeons
Journal of Indian Association of Pediatric Surgeons
                                                   Official journal of the Indian Association of Pediatric Surgeons                           
Year : 2012  |  Volume : 17  |  Issue : 3  |  Page : 132--134

Isolated mucormycosis in a post-pyeloplasty kidney in an immuno-competent child

Anjan K Dhua1, Shalini Sinha1, Yogesh K Sarin1, Nita Khurana2,  
1 Department of Pediatric Surgery, Maulana Azad Medical College, Delhi, India
2 Department of Pathology, Maulana Azad Medical College, Delhi, India

Correspondence Address:
Yogesh K Sarin
Professor and Head, Department of Pediatric Surgery, Maulana Azad Medical College, Delhi - 110002


A child with isolated renal mucormycosis who was successfully treated with systemic anti-fungal therapy and nephrectomy is reported.

How to cite this article:
Dhua AK, Sinha S, Sarin YK, Khurana N. Isolated mucormycosis in a post-pyeloplasty kidney in an immuno-competent child.J Indian Assoc Pediatr Surg 2012;17:132-134

How to cite this URL:
Dhua AK, Sinha S, Sarin YK, Khurana N. Isolated mucormycosis in a post-pyeloplasty kidney in an immuno-competent child. J Indian Assoc Pediatr Surg [serial online] 2012 [cited 2020 Jul 7 ];17:132-134
Available from:

Full Text


Zygomycosis is an opportunistic fungal infection involving multiple organ systems in an immuno-deficient individual. Isolated renal mucormycosis (IRM) has been seldom reported and is even rarer in children. [1],[2],[3] We describe a case of unilateral IRM in an operated case of bilateral pelvi-ureteric junction obstruction (PUJO). The patient was managed successfully with amphotericin B and nephrectomy.

 Case Report

A 7-year-old boy presented with left flank pain and intermittent fever for 10 days. He was antenatally diagnosed as bilateral PUJO. Postnatal differential renal function on Diethylenetriamine pentaacetic acid (DTPA) scan was 17%. He underwent an open dismembered pyeloplasty on the left side followed by the right side at the age of 4 months and 1.5 years respectively. He was on regular follow-up for 5 years and doing well. However, he had not visited our pediatric urology clinic in the last 1 year. The current presentation was attributed to left sided pyonephrosis and empirical intravenous antibiotics were started. The patient was hemodynamically stable and the systemic examination was unremarkable except for tenderness in the left flank. The leucocyte count, kidney function tests and blood sugar levels were within normal range. The urine culture was negative. ELISA for HIV was also negative. An ultrasonography showed grossly dilated pelvicalyceal system with thinning of renal parenchyma and echogenic debris. A contrast enhanced CT scan [Figure 1]a corroborated the sonographic findings.{Figure 1}

A needle biopsy was done to rule out suspicion of a neoplastic lesion and the histopathology revealed presence of broad fungal hyphae interspersed with inflammatory cells. The branching pattern of the hyphae was suggestive of mucormycosis. The urine and blood samples for fungal cultures were negative. Intravenous amphotericin B (0.6-1 mg/kg/day) was initiated and his fever subsided. After 4 weeks of therapy, a repeat CT scan showed only partial resolution of the mass [Figure 1]b; hence nephrectomy was done [Figure 2]. Relative function of the left kidney was 20% on pre-nephrectomy DTPA scan. Amphotericin B was continued for 1 more week in the post operative period. The histopathology of the nephrectomy specimen revealed fungal hyphae [Figure 2]a and b. Propensity of the organism to invade the vessels was also demonstrated [Figure 2]c. His recovery was uneventful and is asymptomatic at 2 months follow up.{Figure 2}


Zygomycosis is a fatal condition especially in an immunodeficient subject. The mortality of different forms of mucormycosis reaches 75-100% in most series. The four common clinical presentations of mucormycosis are rhinocerebral, pulmonary, gastrointestinal [4] and disseminated forms. Involvement of the kidneys has been reported in up to 20% of the cases with disseminated forms. [5] Involvement of a single organ such as bone, heart and kidney is extremely rare. [6],[7] In 2004, Jianhong et al. [8] reported 3 pediatric cases with IRM without an underlying predisposing condition. [Table 1] summarizes the cases of IRM in children aged 14 years and below, reported in English literature hitherto. Survival for IRM is estimated to be 65%. [11] {Table 1}

Clinically, most patients with IRM present with fever, flank pain, tenderness, gross hematuria or pyuria. [6],[9] It has been frequently misdiagnosed previously as renal abscess and nephroblastoma. [8] Blood and urine cultures are often negative and diagnosing mucormycosis almost always requires a high index of clinical suspicion. Histopathologic evidence of fungal invasion of the tissues is diagnostic.

There is a general consensus in the literature that early institution of amphotericin B followed by nephrectomy provides a satisfactory outcome. [9] The need for nephrectomy arises because of the propensity of the organism to invade the vessels and produce thrombosis thereby rendering the delivery of amphotericin B to the affected tissues unpredictable. [12]

Our patient was immuno-competent, although he had an anatomic abnormality in the form of PUJO, which had already been corrected surgically. The source of infection remained elusive as all diagnostic work up was negative.

A question that may arise is whether nephrectomy could have been avoided. Rogenes et al.[11] reviewed the contemporary literature and found that none of the cases of renal mucormycosis survived with amphotericin B alone. Similar experience was also reported by Gupta et al. [6] However, there are contrary reports in the literature, albeit scanty, of cases treated solely by amphotericin B. Levy [13] in 1995 reported a case of renal mucormycosis with HIV who received 4 months of amphotericin B treatment alone. The patient survived for 6 months without any symptoms related to the mucormycosis and died of an unrelated cause. Later in 1998, David et al. [14] reported successful management of an adult with AIDS and IRM with amphotericin B alone. There is a single report from India of a 10 -year -old boy with IRM that was successfully treated with amphotericin B alone. [9] Despite these isolated reports, our experience was quite to the contrary and is in tune with the trend observed in contemporary literature.

The clinical pattern of persistence of infection in the kidney and non-progression to disseminated form of mucormycosis provides emphasis to the argument that IRM must be considered as a separate disease entity as has been earlier suggested by Jianhong et al. [8] Our case also highlights that IRM has an overall favorable outcome compared to other forms of invasive mucormycosis and that early institution of amphotericin-B, combined with nephrectomy offers the best chance for cure.


1Raghavan R, Date A, Bhaktaviziam A. Fungal and nocardial infections of the kidney. Histopathology 1987;11:9-20.
2Davila RM, Moser SA, Grosso LE. Renal mucormycosis: A case report and review of the literature. J Urol 1991;145:1242-4.
3Pickles R, Long G, Murugasu R. Isolated renal mucormycosis. Med J Aust 1994;160:514-6.
4Sarin YK. Intestinal mucormycosis in a neonate: A case report and review. J Indian Assoc Pediatr Surg 2010;15:98-100.
5Ingram CW, Sennesh J, Cooper JN, Perfect JR. Disseminated zygomycosis: Report of four cases and review. Rev Infect Dis 1989;11:741-54.
6Gupta KL, Joshi K, Sud K, Kohli HS, Jha V, Radotra BD, et al. Renal zygomycosis: An under-diagnosed cause of acute renal failure. Nephrol Dial Transplant 1999;14:2720-5.
7Prout GR Jr, Goddard R. Renal mucormycosis: Survival after nephrectomy and amphotericin B therapy. N Engl J Med 1960;263:1246-8.
8Jianhong L, Xianliang H, Xuewu J. Isolated renal mucormycosis in children. J Urol 2004;171:387-8.
9Chakrabarti A, Das A, Sharma A, Panda N, Das S, Gupta KL, et al. Ten years' experience in zygomycosis at a tertiary care centre in India. J Infect 2001;42:261-6.
10Sharma R, Shivanand G, Kumar R, Prem S, Kandpal H, Das CJ, et al. Isolated renal mucormycosis: An unusual cause of acute renal infarction in a boy with aplastic anaemia. Br J Radiol 2006;79:e19-21.
11Rogenes V, Vick S, Pultizer DR. Isolated renal mucormycosis. Infect Urol 1998;113:78-83.
12Langston C, Roberts DA, Porter GA, Bennett WM. Renal phycomycosis. J Urol 1973;109:941-4.
13Levy E, Bia MJ. Isolated renal mucormycosis: Case report and review. J Am Soc Nephrol 1995;5:2014-9.
14Weng DE, Wilson WH, Little R, Walsh TJ. Successful medical management of isolated renal zygomycosis: Case report and review. Clin Infect Dis 1998;26:601-5.