Journal of Indian Association of Pediatric Surgeons
Journal of Indian Association of Pediatric Surgeons
                                                   Official journal of the Indian Association of Pediatric Surgeons                           
Year : 2008  |  Volume : 13  |  Issue : 2  |  Page : 57--60

Embryogenesis of bladder exstrophy: A new hypothesis


Bharati Kulkarni, Navin Chaudhari 
 Department of Paediatric Surgery, Lokmanya Tilak Municipal General Hospital, Sion, Mumbai - 400 022, India

Correspondence Address:
Bharati Kulkarni
A2/13/5, Millennium Towers, Sector 9, Sanpada, Navi Mumbai - 400 705
India

Aims and Objective: To postulate a hypothesis to explain the embryogenesis of exstrophy bladder based on our clinical observations. Materials and Methods: In 27 cases of exstrophy, we measured the distance between the lowermost inguinal skin crease to the root of the penis (clitoris) (B) and the distance between the penis (clitoris) and the scrotum (labia majora) (C). These were compared with age, height and XP distance (distance between xiphisternum and symphysis pubis) matched control group of normal children. The distance between the lowermost inguinal skin crease and the penis (clitoris) (A) was measured in control group. Results: The observation was A = B + C. This implies that in exstrophy bladder, the position of the penis (clitoris) has moved cephalad from the lower border of A to the junction of B and C. Conclusion: Based on the observations, we postulate that abnormal origin of genital tubercle may be the cause of exstrophy bladder. The abnormal origin of primordia of the genital tubercle in more cephalad direction than normal causes wedge effect, which will interfere with the medial migration of the mesoderm as well as the midline approximation of mesodermal structures in the lower abdominal wall, thereby resulting in the exstrophy of bladder.


How to cite this article:
Kulkarni B, Chaudhari N. Embryogenesis of bladder exstrophy: A new hypothesis.J Indian Assoc Pediatr Surg 2008;13:57-60


How to cite this URL:
Kulkarni B, Chaudhari N. Embryogenesis of bladder exstrophy: A new hypothesis. J Indian Assoc Pediatr Surg [serial online] 2008 [cited 2019 Jun 16 ];13:57-60
Available from: http://www.jiaps.com/article.asp?issn=0971-9261;year=2008;volume=13;issue=2;spage=57;epage=60;aulast=Kulkarni;type=0