Journal of Indian Association of Pediatric Surgeons
Journal of Indian Association of Pediatric Surgeons
                                                   Official journal of the Indian Association of Pediatric Surgeons                           
Year : 1997  |  Volume : 2  |  Issue : 4  |  Page : 104--109

Contralateral testicular damage in unilateral undescended testis in rats.


M Srinivas, S Agarwala, SN Das, C Saha, DK Mitra 
 All Institute of Medical Sciences, New Delhi-110029, India

Correspondence Address:
M Srinivas
All Institute of Medical Sciences, New Delhi-110029
India

ABSTRACT: The aim of this study is to evaluate DNA ploidy as a tool to detect subtle morphological changes in the contralateral (C/L) descended testis, and to detect serum antisperm antibodies, in rats with experimentally created unilateral undescended testis (U/L UDT) and to correlate these changes to fertility potential. Wistar rat pups with experimentally created U/L UDT at 2 days of age were followed-up till adulthood to detect any alteration in fertility potential. Changes in DNA ploidy of the C/L descended testicular tissue and the levels of antisperm antibodies were compared to controls and those rats with U/L UDT who received immunosuppression and those in whom the UDT was later excised. Neither DNA ploidy changes or anti-sperm antibodies were found in those rats with U/L UDT who were simultaneously administered immuno-suppressants or those in whom the UDT had been excised at 30 days of age. The presence of serum anti-sperm antibodies and a significant reduction in the haploid cell population in the C/L testicular tissue of rats with U/L UDT correlated well with a significant reduction of fertility in this group. Reduction in C/L haploid cell population and the presence of serum anti-sperm antibodies correlates well with significantly decreased fertility in rats with U/L UDT and is indicative of immunologically mediated C/L testicular damage which is initiated and perpetuated by the continuing presence of the undescended testis.


How to cite this article:
Srinivas M, Agarwala S, Das S, Saha C, Mitra D. Contralateral testicular damage in unilateral undescended testis in rats. J Indian Assoc Pediatr Surg 1997;2:104-109


How to cite this URL:
Srinivas M, Agarwala S, Das S, Saha C, Mitra D. Contralateral testicular damage in unilateral undescended testis in rats. J Indian Assoc Pediatr Surg [serial online] 1997 [cited 2019 Oct 22 ];2:104-109
Available from: http://www.jiaps.com/article.asp?issn=0971-9261;year=1997;volume=2;issue=4;spage=104;epage=109;aulast=Srinivas;type=0