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     Journal of Indian Association of Pediatric Surgeons
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LETTER TO THE EDITOR
Year : 2015  |  Volume : 20  |  Issue : 1  |  Page : 52
 

Bile in various hepatobiliary disease states


1 Medical Science Unit, Hainan Medical University, China
2 Visiting Professor in Tropical Medicine Unit, Hainan Medical University, China

Date of Web Publication27-Nov-2014

Correspondence Address:
Sim Sai Tin
Medical Center, Shantou
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9261.145562

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How to cite this article:
Tin SS, Wiwanitkit V. Bile in various hepatobiliary disease states . J Indian Assoc Pediatr Surg 2015;20:52

How to cite this URL:
Tin SS, Wiwanitkit V. Bile in various hepatobiliary disease states . J Indian Assoc Pediatr Surg [serial online] 2015 [cited 2019 Nov 21];20:52. Available from: http://www.jiaps.com/text.asp?2015/20/1/52/145562


Sir,

We would like to discuss the report on "bile in various hepatobiliary disease states." [1] Verma et al. concluded that the components of bile show a close correlation with various clinical and prognostic markers. There is a very close correlation between these parameters and the clinical severity, disease progression and final outcome. [1] In fact, bile analysis is an old laboratory test in body fluid examination. Based on the report by Verma et al., the analysis might seem useful in clinical diagnosis. However, there are some concerns to be addressed. First, the bile component can be affected by several physiological and pathological conditions. For example, dehydration in children might concentrate the bile. [2] In addition, some underlying genetic diseases such as hemoglobinopathies might alter the component of the bile. [3] These factors have to be considered in bile analysis; however, it is not well assessed and mentioned in the report by Verma et al. [1]



 
   References Top

1.
Verma A, Bhatnagar V, Prakash S, Srivastava AK. Analysis of bile in various hepatobiliary disease states: A pilot study. J Indian Assoc Pediatr Surg 2014;19:151-5.  Back to cited text no. 1
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2.
Devor AW, Marlow HW. Dehydration of cholic acid. J Am Chem Soc 1946;68:2101.  Back to cited text no. 2
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3.
Barbi G, Annoni G. Thalassemia trait and the lithogenicity of bile. Minerva Med 1977;68:2997-3000.  Back to cited text no. 3
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