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Journal of Indian Association of Pediatric Surgeons
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Table of Contents   
CASE REPORT
Year : 2011  |  Volume : 16  |  Issue : 1  |  Page : 24-25
 

Multiloculated cervical thymic cyst


1 Department of Pathology, Vydehi Institute of Medical Sciences and Research Center, Bangalore, India
2 Department of Otorhinolaryngology, Vydehi Institute of Medical Sciences and Research Center, Bangalore, India

Date of Web Publication3-Jan-2011

Correspondence Address:
J Niranjan
˝, 16th D Main, HAL II Stage, Bangalore - 560 008
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9261.74518

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   Abstract 

In this study, we report a rare case of cervical thymic cyst in an 8-year-old child.


Keywords: Cervical, thymic cyst, thymus


How to cite this article:
Niranjan J, Santosh K V, Prabhakar G. Multiloculated cervical thymic cyst. J Indian Assoc Pediatr Surg 2011;16:24-5

How to cite this URL:
Niranjan J, Santosh K V, Prabhakar G. Multiloculated cervical thymic cyst. J Indian Assoc Pediatr Surg [serial online] 2011 [cited 2018 May 25];16:24-5. Available from: http://www.jiaps.com/text.asp?2011/16/1/24/74518



   Introduction Top


The thymus is derived mostly from the third pharyngeal pouch. During embryogenesis, the primordial thymic tissue descends down into the mediastinum, initially connected to the pharynx by hollow structures named "thymopharyngeal ducts". [1] During its path of descent, remnants of thymic tissue may be left behind, leading to formation of a cyst. Cervical thymic cysts are rare, [2] and most are unilocular. [3] Thymic cysts account for 0.3% of pediatric congenital cervical cysts. [3] A variant which communicates with the pharynx is designated "thymopharyngeal duct cyst," [4]


   Case Report Top


An 8-year-old child presented with a swelling involving the upper cervical region on the left side of the neck for 3 months. The swelling was soft to cystic in consistency and was situated in the carotid triangle. The lesion had diffuse borders, smooth external surface, and appeared fluctuant. On clinical examination, the lesion was diagnosed as "branchial cyst". A fine needle aspiration cytology performed elsewhere had been reported as "benign retention cyst".

The ultrasound examination showed a cystic mass that measured 3.7 × 2.5 × 2.4 cm in its greatest dimension. The lesion was surgically excised. During surgery, the lesion was found connected to the pharynx by a firm cord. The excised specimen was a multiloculated pale brown, cystic tissue with a knobby surface, 5 × 4 × 2 cm. On sectioning, the surface displayed multiple locules between 0.3 and 1 cm in diameter with pale brown serous fluid; separated by fine translucent septae with tiny grey-white nodules [Figure 1]. On microscopic examination, thymic tissue with lobules of lymphoid follicles with germinal centers and large keratinous to amorphous appearing Hassal's corpuscles were present. Many of the Hassal's corpuscles had a distended appearance with flat epithelial lining and luminal debris, suggesting early cyst formation [Figure 2]. The stroma had cholesterol clefts with foreign body reaction.
Figure 1: Cut section of the specimen revealing brownish multiloculated cyst with thin septae

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Figure 2: Microphotograph showing degenerating Hassal's corpuscle within thymic lymphoid tissue (H and E, ×400)

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   Discussion Top


Cervical thymic cysts are uncommon lesions, more often affecting the left side of the neck, with a slight male preponderance. [4] They usually manifest during the first decade of life, as a slow, painless mass in the region between the angle of mandible to sternum, in the vicinity of the carotid sheath, located along the path of descent of embryonic tissue. [1] Thymic cysts may be connected to the pyriform fossa through the thyrohyoid membrane. [5]

Contrast enhanced computed tomogram (CT) scans can differentiate thymic cysts from other pediatric neck swellings, such as branchial cleft cysts and lymphangiomas; the second branchial cysts are located superficial and lateral to internal jugular vein and common carotid artery, and lymphangiomas are found in the posterior triangle of the neck while thymic cysts are situated in close association with the carotid sheath, between internal jugular vein and carotid vessels. [6],[7] Also, thymic cysts tend to be longer, extending toward the anterosuperior mediastinum. [7]

The cysts measure up to 15 cm in diameter, most are unilocular. [4] The cyst contents are either clear, serous or brownish fluid. Microscopic diagnosis requires that the cyst wall contains thymic tissue. [1] Microscopy is characterized by typical thymic tissue with large, degenerating Hassal's corpuscles and cysts lined by single or multilayered epithelium. The parathyroid gland may be found in the periphery of the cyst, indicative of the common embryologic origin from the third branchial pouch. [8]

The origin of cervical thymic cysts has been attributed to two differing mechanisms. The unilocular cysts are thought to be due to the persistence of thymopharyngeal duct, while the multilocular cysts result from cystic degeneration of thymic Hassal's corpuscles. [4],[9]

Surgical removal is the treatment of choice. Thymectomy during childhood has been documented to produce impairment of immune status in later life. [10] Hence, it is imperative that the existence of mediastinal thymus is confirmed before proceeding with the excision of the cervical thymic tissue. Magnetic Resonance Imaging (MRI) and Fine Needle Aspiration Cytology (FNAC) may be performed to confirm the presence of a mediastinal thymus; and in the absence of which the surgical procedure should be deferred. [6] Cervical thymic cysts are not known to recur or undergo malignant transformation.

 
   References Top

1.Verbin RS, Barnes L. Cysts and Cyst-like Lesions of the Oral Cavity. Jaws and Neck. Surgical Pathology of the Head and Neck. 2 nd ed. Switzerland: Marcel Dekker AG; 2001.  Back to cited text no. 1
    
2.Sanei MH, Berjis N, Mesbah A. Cervical thymic cyst, A case report and review of the literature. J Res Med Sci 2006;11:339-42.  Back to cited text no. 2
    
3.Hsieh YY, Hsueh S, Hsueh C, Lin JN, Luo CC, Lai JY, et al. Pathological analysis of congenital cervical cysts in children: 20 Years of Experience at Chang Gung Memorial Hospital. Chang Gung Med J 2003;26:107-13.  Back to cited text no. 3
    
4.Dehner LP. Congenital anomalies of the head and neck. In: Pilch BZ, editor. Head and Neck Surgical Pathology. Philadelphia: Lippincott Williams and Wilkins; 2001.  Back to cited text no. 4
    
5.Koeller KK, Alamo L, Adair CF, Smirniotopoulos JG. Congenital cystic masses of the neck: Radiologic, pathologic correlation. Radiographics 1999;19:121-46.  Back to cited text no. 5
    
6.Kaufman MR, Smith S, Rothschild MA, Som P. Thymopharyngeal duct cyst. Arch Otolaryngol Head Neck Surg 2001;127:1357-60.  Back to cited text no. 6
    
7.Daga BV, Chaudhary VA, Dhamangaokar VB. Case Report: CT diagnosis of thymic remnant cyst / thymopharyngeal duct cyst. Indian J Radiol Imaging 2009;19:293-5.  Back to cited text no. 7
[PUBMED]  Medknow Journal  
8.Eglender M, Kfir E, Ben-Dor D. Cervical thymic cyst: Unusual age and site. Isr Med Assoc J 2009;11:191-2.  Back to cited text no. 8
    
9.Prasad KK, Gupta RK, Jain M, Kar DK, Agarwal G. Cervical thymic cyst: Report of a case and review of the literature. Indian J Pathol Microbiol 2001;44:483-5.  Back to cited text no. 9
[PUBMED]  Medknow Journal  
10.Brearley S, Gentle TA, Baynham MI, Roberts KD, Abrams LD, Thompson RA. Immunodeficiency following neonatal thymectomy in man. Clin Exp Immunol 1987;70:322-7.  Back to cited text no. 10
    


    Figures

  [Figure 1], [Figure 2]


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    Abstract
    Introduction
    Case Report
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