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ORIGINAL ARTICLE
Year : 2009  |  Volume : 14  |  Issue : 1  |  Page : 19-23
 

Surgical considerations in pediatric necrotizing fasciitis


Department of Pediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, U.P., India

Date of Web Publication31-Jul-2009

Correspondence Address:
A N Gangopadhyay
Department of Pediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, UP
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9261.54816

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   Abstract 

Background: Necrotizing fasciitis (NF) is a serious infection of soft tissues. This paper presents experience with pediatric NF and suitability of conservative surgery in its management. Materials and Methods : In this retrospective study, 70 patients of NF were managed during the study period of eight years. The study was divided into two time periods- first period (June 1998 to June 2001- group 1) and second period (June 2001 to June 2006- group 2). The parameters studied were age, sex, site of involvement and treatment. The treatment included intravenous antibiotics, supportive therapy and either aggressive (group 1) or conservative surgery (group 2). Results: Age of presentation ranged from 10 days to 11 years. Male to female ratio was 1.69:1. Back was the commonest site to be involved. Culture reports were polymicrobial in 70% with predominance of Staphylococcus species. Predisposing factors included malnourishment, boils, scratch injury, intravenous cannulation and injections. Conservative surgery had better outcome in terms of hospital stay, complications and cost of treatment. Conclusion: NF is a serious and disease which requires immediate and all out attention. Early diagnosis, aggressive supportive treatment and conservative surgery improve survival.


Keywords: Children, debridement, necrotizing fasciitis


How to cite this article:
Pandey A, Gangopadhyay A N, Sharma S P, Kumar V, Gopal S C, Gupta D K. Surgical considerations in pediatric necrotizing fasciitis. J Indian Assoc Pediatr Surg 2009;14:19-23

How to cite this URL:
Pandey A, Gangopadhyay A N, Sharma S P, Kumar V, Gopal S C, Gupta D K. Surgical considerations in pediatric necrotizing fasciitis. J Indian Assoc Pediatr Surg [serial online] 2009 [cited 2019 Nov 12];14:19-23. Available from: http://www.jiaps.com/text.asp?2009/14/1/19/54816



   Introduction Top


Necrotizing fasciitis (NF) is a life threatening condition consisting of soft tissue infection with rapid progression and wide spread fascial necrosis. [1] All age groups, including neonates can be affected.

The mainstay of treatment is antibiotics and surgery which consists of debridement. In the standard management of NF, both for children and adults early and aggressive debridement is advocated. [1],[2],[3],[4],[5] There are some studies suggesting that aggressive surgery can be delayed until the patient settles which may help decrease morbidity of the condition. [6],[7],[8] Hence, an important point of consideration is timing and type of surgery in cases of NF. This study was done to see the trends of NF along with its surgical considerations and efficacy of treatment with delayed surgery. The purpose of the study was to see if delayed debridement benefits children and neonates.


   Materials and Methods Top


This was a retrospective study done from June 1998 to June 2006. All NF patients admitted were studied. The diagnosis of NF was made on clinical and microbiological basis. Patients were studied for age, sex, area of involvement, microbiology, duration of stay, and predisposing factors.

The study was divided in to two time periods. In the first period (June 1998 to June 2001), early aggressive surgery was done (group 1). During this period, debridement was done immediately after the diagnosis of NF was made either in the cellulitic stage, with dusky blue patch or when gangrene of the involved skin had occurred. It involved complete removal of the necrotic tissue until the viable bleeding tissue was visible under the necrotic bed. The procedure was carried out in the operation theatre under general anesthesia. Antibiotics were used to cover gram positive (Ceftriaxone 50 mg/kg IV 12 hourly or Co amoxycalv 30 mg/kg IV 8 hourly), gram negative (Amikacin 7.5mg/kg IV 12 hourly) and anaerobes (Ornidazole 10 mg/kg IV 12 hourly). IV fluid was given to replace volume deficit. Analgesia was provided by intramuscular (IM) Pentazocine (0.5mg/kg). If required, IM Diazepam (0.1to 0.3 mg/kg) was given for restlessness and agitation.

The second time period ranged from June 2001 to June 2006 (group 2). The management included blood investigation (Hemogram, renal function tests) before and after treatment, blood transfusion, intravenous (IV) antibiotics and debridement. The antibiotics and supportive management were same as for the group 1. In both the groups, the counts were repeated on alternate days.

In group 2, debridement was done three to five days after starting antibiotics intravenously and on formation of dry black skin loosely adhered to its base and separating from surrounding healthy skin [Figure 1]. This procedure was done under sedation. It included careful removal of only dead skin [Figure 2] along with daily washing with normal saline and dressing with povidone iodine solution and placentrex gel. No surgical intervention was attempted in acute stage. Dressing was done repeatedly with povidone iodine lotion and placentrex gel (Human placental extract, Albert David, Kolkata, India), both before and after debridement till the wound had healthy granulation tissue [Figure 3]. The patients were discharged when they were afebrile, taking orally, blood counts were normal (white blood cells WBC less than 11000/mm 3 ) and the wound was healthy and granulating.

The cost of treatment was evaluated on the basis of all expenses needed for surgery, medications, investigations and blood transfusions. This also included the expenses incurred by the hospital on the patient such as free drugs etc.

The outcome was evaluated on the basis of hospital stay, complication and mortality.

All the data was entered into the Microsoft Excel sheet. The statistical analysis was done using SPSS 12.0 version for Windows. The analysis was done using paired t-test , Chi square test, Fisher exact test and one way ANOVA. The values are expressed as mean plus/minus standard deviation. The P value of less than 0.05 was considered as statistically significant.


   Results Top


The total number of patients in groups 2 and 1 was 49 and 21 respectively. Both the groups had comparable age and sex distribution [Table 1]. In both groups, the mode of presentation was cellulitis followed by a rapidly developing black patch of skin that was preceded by features of septicemia. In group 2, these included fever 43 (87.7%), lethargy 41(83.6%), anorexia 40 (81.6%), seizures two (4%) and loss of consciousness one (2%). In group 1, the features of septicemia noticed were fever 18 (85.7%), lethargy 18 (85.7%) and anorexia 15 (71.4%). Thus, both the groups had comparable mode of presentations ( P greater than 0.05).

In group 2 the area of involvement included back 18 (36.7%), neck and scalp nine (18.3%), thigh eight (16.3%), abdomen six (12.2%), chest five (10.2%) and arm three (6.1%). In group 1 the area of involvement included back 10 (47.62%), thigh four (19.05%), neck and scalp three (14.29%), abdomen two (9.52%) and arm two (9.52%). Both groups were comparable for the area of involvement [ P greater than 0.05, [Table 1]].

In group 2, the culture reports were polymicrobial in 32 (65.3%) and rests were unimicrobial. There was predominance of Staphylococcus species (73.4% of total), S. aureus being 30 (61.2%) and S.epidermidis six (12.2%), others being Streptococcus six (12.2%), E. coli four (8.1%) and Klebsiella three (6.1%). In group1 polymicrobial culture reports were noticed in 16 (76.19%) patients, rest being unimicrobial. Both the groups were comparable regarding the type of culture [ P greater than.05, [Table 1]]. Staphylococcus species predominated in this group also (80.95% of total). S. aureus was noticed in 13 (61.9%), S. epidermidis 4 (19.05%), Streptococcus three (14.29%) and E. coli one (4.76%).

Hemogram revealed hemoglobin in range of seven gm % to 12 gm % (mean 8.23 plus/minus 1.39 gm %) in both the groups. The serum urea and creatine levels ranged from 15 to 39 mg % (mean 21.23 plus/minus 6.17 mg %) and 0.5 to 1.1 mg % (mean 0.66 plus/minus 0.15 mg %) respectively in both the groups. Total leukocyte counts were above 13000/mm 3 with predominance of neutrophils (greater than 75%). C reactive protein (CRP) was done in 21 patients in group 2 and was uniformly raised. It was not done in rest of patients due to cost factor. In group1 CRP was not done in any of the patients because of unavailability of the facility at that time. Blood transfusion raised the hemoglobin to the level of 12 gm % to 15 gm % (mean 13.5 plus/minus 1.06 gm %) in both the groups. Total and differential leukocyte counts (TLC and DLC) normalized after five to seven days (mean 6.14 plus/minus.76 days) of treatment in group 2 and seven to 10 days (mean 8.57 plus/minus.98) in group 1 [ P less than 0.001, [Table 1]]. Intravenous antibiotics were continued for at least 10 days.

Patients were discharged after having healthy granulating wound to be healed by secondary intention or skin grafting. In group 2 36 (73.4%) patients were allowed to heal by secondary intention and the remaining 13 (26.5%) had skin grafting. In group 1 14 (66.67%) patients had healing by secondary intention and seven (33.33%) had skin grafting. The duration of hospital stay was significantly higher in group 1 [Table 1].

In groups 1 and 2 complications occurred in 10 (52.38%) and 11 (20.4%) patients respectively. These included septicemias, secondary wound infection, disseminated intravascular coagulation and functional disability [Table 2].

In group 2, 10 patients (20.4%) expired. Three of them were premature neonates. All had poor general condition and didn't respond to the treatment. Predisposing factors included malnourishment 30 (61.2%), boils 29 (59.1%), scratch injury six (12.2%), intravenous cannulation three (6.2%), and injections two (4.1%). In group 1, five (23.81%) patients expired [ P greater than.05 for mortality, [Table 1]].

On comparing this modality with the approach of aggressive early debridement, we found conservative surgery to be superior to conventional surgery [Table 1],[Table 2],[Table 3]. The results were statistically significant in terms of hospital stay, complications and cost of treatment.


   Discussion Top


NF is seen primarily in adults [2] but there are some pediatric series also. [2],[3],[4],[8],[9],[10] Overall male to female ratio in our study was 1.69:1. Legbo et al . reported the ratio to be of 1.7:1, [10] suggesting a slightly higher incidence in male patients.

The commonest area of involvement in our study was back which corresponds with other studies. [2],[10] Most of the patients had history of some inciting agent detailed in the results with the predisposing factors such as boils, scratch etc. There is a possibility of some cause in rest of the patients which the attendants probably failed to notice. The common inciting factors reported in literature are minor injuries [11] surgical and traumatic wounds, [12] varicella and immunosuppression. [3] It has been shown to be associated with immunodeficiency and even HIV infection in case reports. [13],[14]

Majority of the culture reports were polymicrobial which is in accordance with the various retrospective studies and reviews, predominant species being Staphylococcus and Streptococcus . [8],[10],[11],[15] Our patients belonged to poor socio-economic class with poor nutritional status and hence poor immunity. NF can be severe in such condition, probably due to improper care given to the children and ignorance in this section of the society. The cost effective method adopted by us was transfusion of fresh blood in every patient we treated. It also helped in building up of hemoglobin which is frequently low in this part of the world. TLC and DLC were prime indicators of response to treatment as normalization of counts occurred after 5 to 10 days of intravenous antibiotics. It can be argued that fresh blood contains leukocytes which can increase the TLC, thereby blunting our assessment that is based on normalization of counts. We, however, believe that it is not possible as neutrophils, which form major pool of leukocytes survive in circulation for about six hours [16] and we measured TLC on every alternate day.

Early diagnosis is important for early start of treatment. There are various reports of newer diagnostic modalities like USG, CT and MRI to help in early diagnosis with good results. [17],[18],[19]

Supportive therapy is needed in form of intravenous fluids, pain control [20] and oxygen supplementation if needed. As literature suggests predominance of polymicrobial flora in NF, [21] our reports despite being unimicrobial or polymicrobial we used ceftriaxone/co amoxyclav for gram positive, aminoglycoside for gram negative and ornidazole for anaerobic organisms as first line drugs. On the basis of culture reports and clinical response others drugs were used viz. sulbactam and cefoparazone, cefipime as per their dose with good response.

We adopted what we call as conservative surgery in managing the patient after noticing some success with delayed debridement in the literature. [6],[7] We were able to achieve healthy granulating wound in all patients in whom conservative debridement was done. For tissue healing, we used the Placentrex gel which is human placental extract. It promotes healing and is also claimed to be having some anti inflammatory activity. There are reports of conservative management of NF with good results. [6],[7],[8] We don't prefer the aggressive surgery for the condition like others. [2],[3],[4],[5],[9],[11]

According to the proponents of aggressive surgery, total excision of all necrotic tissues including muscle, fascia and skin is needed to control the progression of NF and ongoing release of bacterial toxins. [9] In various retrospective studies and reviews, early and aggressive debridement has been recommended for favorable results; [2],[3],[4],[5],[9],[10],[11] however, none of them has commented up on delayed debridement, suggesting that it was never considered as an initial choice. We are in accordance of conservative surgery like Wakhlu et al . [8] as we believe that extensive early surgical debridement in the acute stage of infection requires multiple blood transfusions and intensive care management and adds surgical stress over the systemic effects of the infection. It is hypothesized that debridement during the acute stage of NF may promote entry of the infecting organism through newly opened vascular channels leading to flaring of the infection. Though Bingol-Kologlu et al . [9] recommended early debridement, it is to be noticed that cutaneous gangrene had already occurred because of delayed admission in their patients which is more or less like delayed surgery.

Our results show that conservative surgery is worth attempting as an initial choice [Table 1],[Table 2],[Table 3]. Though complications were not statistically significant in both the groups except secondary wound infection [Table 1], we believe that it was due to the less number of patients in the group1. Moreover, overall percentage of complications was greater in group1 and was statistically significant [Table 3].

The limitation of our study could be smaller group of patients in which aggressive surgery was done (group 1). This may be a reason for insignificant values for the complications discussed in the [Table 2]. The other limitation of the study could be historic controls; however, as this was not a randomized control trial we had to rely on them.

To conclude, NF in children can be a serious disease which requires immediate and all out attention. High index of suspicion, early diagnosis, aggressive supportive treatment and conservative surgery instead of aggressive surgery as and when needed may improve survival. A large prospective study comparing both the treatment modalities may throw additional light on the feasibility of conservative surgery.

 
   References Top

1.Kihiczak GG, Schwartz RA, Kapila R. Necrotizing fasciitis: A deadly infection. J Eur Acad Dermatol Venereol 2006;20:365-9.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]
2.Hsieh WS, Yang PH, Chao HC, Lai JY. Neonatal necrotizing fasciitis: A report of three cases and review of the literature. Pediatrics 1999;103:e53.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.Fustes-Morales A, Gutierrez-Castrellon P, Duran-Mckinster C, Orozco-Covarrubias L, Tamayo-Sanchez L, Ruiz-Maldonado R. Necrotizing fasciitis: Report of 39 pediatric cases. Arch Dermatol 2002;138:893-9.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Moss RL, Musemeche CA, Kosloke AM. Necrotizing fasciitis in children: Prompt recognition and aggressive therapy improve survival. J Pediatr Surg 1996;31:1142-6.  Back to cited text no. 4    
5.Bilton BD, Zibari GB, McMillan RW, Aultman DF, McDonald JC. Aggressive surgical management of necrotizing fasciitis serves to decrease mortality: A retrospective study. Am Surg 1998;64:397- 401.  Back to cited text no. 5  [PUBMED]  
6.Chen JW, Broadbent RS, Thomson IA. Staphylococcal Neonatal necrotizing fasciitis: Survival without radical debridement. N Z Med J 1998;111:251-3.  Back to cited text no. 6  [PUBMED]  
7.Atiyeh BC, Zaatari AM. Necrotizing fasciitis of the upper extremity. J Emerg Med 1994;12:611-3.  Back to cited text no. 7  [PUBMED]  
8.Wakhlu A, Chaudhary A, Tandon RK, Wakhlu AK. Conservative management of necrotizing fasciitis in children. J Pediatr Surg 2006;41:1144-8.  Back to cited text no. 8  [PUBMED]  [FULLTEXT]
9.Bingol-Kologlu M, Yildiz RV, Alper B, Yagmurlu A, Ciftci E, Gokcora IH, et al . Necrotizing fasciitis in children: Diagnostic and therapeutic aspects. J Pediatr Surg 2007;42:1892-7  Back to cited text no. 9    
10.Legbo JN, Shehu BB. Necrotizing fasciitis: Experience with 32 children. Ann Trop Paediatr 2005;25:183-9.  Back to cited text no. 10  [PUBMED]  [FULLTEXT]
11.Fontes RA Jr, Ogilive CM, Miciau T. Necrotizing soft tissue infections. J Am Acad Orthop Surg 2000;8:151-8.  Back to cited text no. 11    
12.Kossman T, Simmen HP, Battaglia H, Brulhart KB, Trentz O. Necrotizing soft tissue infection of the extremities. Helv Chir Acta 1994;60:509-11.  Back to cited text no. 12    
13.Chalwadi UK, Biswal N, Mathai B, Kerur BM, Srinivasan S. Necrotizing fasciitis. Indian J Pediatr 2004;71:1042.  Back to cited text no. 13    
14.Pijnenburg MW, Cotton MF. Necrotizing fasciitis in an HIV-1 infected infant. S Afr Med J 2001;91:500-1.  Back to cited text no. 14  [PUBMED]  
15.Childers BJ, Potyondy LD, Nachreiner R, Rogers FR, Childers ER, Obera KC, et al . Necrotizing fasciitis: A fourteen - year retrospective study of 163 patients. Am Surg 2002;68:109-16.  Back to cited text no. 15    
16.Ganong WF. Circulating body fluids. In: Ganong WF, editor. Review of Medical physiology. 22 nd ed. Singapore: McGraw Hill; 2005. p. 515-46.  Back to cited text no. 16    
17.Chao HC, Kong MS, Lin TY. Diagnosis of necrotizing fasciitis in children. J Ultrasound Med 1999;18:277-81.  Back to cited text no. 17  [PUBMED]  [FULLTEXT]
18.Wysoki MG, Santora TA, Shah RM, Friedman AC. Necrotizing fasciitis: CT characteristics. Radiology 1997; 203:859-63.  Back to cited text no. 18  [PUBMED]  [FULLTEXT]
19.Sato T, Hagiwarw K, Matsuno H, Chiyokura Y, Morimoto S, Kunogi J, et al . A case of necrotizing fasciitis caused by coagulase-negative staphylococcus: Utility of magnetic resonance imaging for the preoperative diagnosis of necrotizing fasciitis. J Infect Chemother 2005;11:160-3.  Back to cited text no. 19    
20.Smeets L, Bous A, Lecog J, Damas P, Heymans O. Necrotizing fasciitis: Diagnosis and treatment. Rev Med Liege 2006;61:240-4.  Back to cited text no. 20    
21.Brook I. Cutaneous and subcutaneous infections in newborns due to anaerobic bacteria. J Perinat Med 2002;30:197-208.  Back to cited text no. 21  [PUBMED]  [FULLTEXT]


    Figures

  [Figure 1], [Figure 2], [Figure 3]
 
 
    Tables

  [Table 1], [Table 2], [Table 3]


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