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Journal of Indian Association of Pediatric Surgeons
     Journal of Indian Association of Pediatric Surgeons
Official journal of the Indian Association of Pediatric Surgeons         
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Year : 2004  |  Volume : 9  |  Issue : 1  |  Page : 20-24

Role of human chorionic gonadotropin (HCG) hormone is undescended testis; a prospective study in 100 children


Dept. of Surgery, Gandhi Medical College Srinagar, Jammu and Kashmir, India

Correspondence Address:
BA Cheechak
Dept. of Surgery, Gandhi Medical College Srinagar, Jammu and Kashmir
India
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Source of Support: None, Conflict of Interest: None


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ABSTRACT: This is a prospective study of 100 children (122 testes) of Cryptorchidism in whom the role of HCG in causing descent of Cryptorchid testis, making impalpable testis to become palpable and making orchidopexy easier and thus improving surgical outcome, has been evaluated. Among the 70 children (86 testes) treated with HCG, 32 were bilateral, 54 were unilateral; 38 testes were impalpable and 48 testes were palpable. The dose of HCG was 5000 IU in the age group of 1-6 years and 10,000 IU in the age group of 7-12 years given in weekly divided intramuscular injections. Patients were evaluated clinically for, descent, palpability and any complication. Among those patients who did not respond to HCG therapy, 30 patients were operated upon and the surgical outcome was compared with 30 patients who were operated without receiving HCG. In our study, descent occurred more in bilateral (50 percent) testis, as compared to unilateral (32 percent) UDT. The overall success rate was 38.3 percent. HCG was more effective in the age group 4-6 years (63 percent in B/L & 33 percent in U/L) than in 7-9 years (50 percent B/L & 35 percent U/L). We found that 47.3 percent impalpable UDT became palpable after HCG treatment. The best response was seen in palpable testis located prescrotally (72.7 percent) and in low canalicular testes (50 percent). Only 15.78 percent impalpable testis descended after HCG. At 4 months follow up, the success rate dropped to 30.2 percent as there was relapse in 7 testes. We found a statistically significant difference (P0.001) between surgical outcome in patients operated after receiving HCG and those operated without receiving HCG.






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  2005 - Journal of Indian Association of Pediatric Surgeons | Published by Wolters Kluwer - Medknow 

Online since 1st May '05