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Journal of Indian Association of Pediatric Surgeons
     Journal of Indian Association of Pediatric Surgeons
Official journal of the Indian Association of Pediatric Surgeons         
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Year : 1999  |  Volume : 4  |  Issue : 4  |  Page : 186-191

The role of OK-432 in the treatment of lymphangiomas.


Division of Surgery, Children's Research Hospital, Kyoto Prefectual University of Medicine, Kyoto,6028566, Japan

Correspondence Address:
S Ogita
Division of Surgery, Children's Research Hospital, Kyoto Prefectual University of Medicine, Kyoto,6028566
Japan
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Source of Support: None, Conflict of Interest: None


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ABSTRACT: The encouraging result of OK-432 in Lymphangioma has led to the formation of Group Study for OK-432 for Lymphangiomas. The effect of intralesional injection of OK-432 in lymphangioma has been studied in this article. OK-432 is a lyophilized biological preparation containing the cells of Streptococcus pyogenes Sustrain treated with benzylpenicillin. OK-432 has lost its streptolysin s-producing ability and losts its toxic activities but produces various immunopharmacological activities and causes shrinkage of lymphangioma. The OK-432 is dissolved in physiological saline and is injected into the lymphatic cyst after aspiration of lymphatic fluid to a maximum doze 0.1mg at each injection. This has been tried in 26 cystic lymphangiomas and 18 cavernous lesion. 1 to 6 injections were given depending on the result of shrinkage of cysts. 92 percent of cystic lymphangioma and 42 percent of cavernous lymphangioma showed favourable result. The OK-432 has also been tried in post-opeative cases with limited success. The adverse reactions of OK-432 injection are fever which subsided with antipiretic drugs, local reaction and hypersensitivity reaction of skin. Other sides effects are general malaise, anorexia and nausea. The author also has described the mechanism action of OK-432.






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