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Journal of Indian Association of Pediatric Surgeons
     Journal of Indian Association of Pediatric Surgeons
Official journal of the Indian Association of Pediatric Surgeons         
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Year : 1999  |  Volume : 4  |  Issue : 2  |  Page : 81-83

Indocyanine green clearance test to evaluate the status of liver functions in extrahepatic biliary obstruction in rats.


Department of Pediatric Surgery and Biochemistry, All Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India

Correspondence Address:
H Dutta
Department of Pediatric Surgery and Biochemistry, All Institute of Medical Sciences, Ansari Nagar, New Delhi-110029
India
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Source of Support: None, Conflict of Interest: None


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ABSTRACT: An experimental model of extrahepatic billary obstruction was created by injecting OK-432 into bile ducts of albine rats. Indocyanin Green (ICG) which is a tricarboxylic acid compound, is taken up and excreted solely by the hepatocytes, was used to assess the hepatocyte function. The ICG was injected intravenously at 3 and 6 weeks following OK-432 injection. Serial arterial blood samples were collected and fractional clearance (K-valu) of ICG was calculated. Study revealed that K-value of ICG is a sensitive marker of hepatocyte function,






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  2005 - Journal of Indian Association of Pediatric Surgeons | Published by Wolters Kluwer - Medknow 

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